Mass Spectrometry-Based N-Glycomics of Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
Mass Spectrometry-Based N-Glycomics of Colorectal Cancer
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. An increased molecular understanding of the CRC pathology is warranted to gain insights into the underlying molecular and cellular mechanisms of the disease. Altered protein glycosylation patterns are associated with most diseases including malignant transformation. Recent advances in mass spectrometry and bioinformatics ha...
متن کاملGlycomics Using Mass Spectrometry
Mass spectrometry (MS), which has advanced rapidly in recent years, is expected to become the tool of choice for high-throughput analysis of relationships between structures and functions of glycans. The structural analysis of glycans using MS employs a number of methods for pretreatment, derivatization, and interpretation. However, since none of these are universally applicable, researchers ha...
متن کاملGlycan reductive isotope-coded amino acid labeling (GRIAL) for mass spectrometry-based quantitative N-glycomics.
A general and simple labeling method, termed glycan reductive isotope-coded amino acid labeling (GRIAL), was developed for mass spectrometry-based quantitative N-glycomics.
متن کاملGlycomics expression analysis of sulfated glycosaminoglycans of human colorectal cancer tissues and non-neoplastic mucosa by electrospray ionization mass spectrometry
OBJECTIVE To determine the presence of glycosaminoglycans in the extracellular matrix of connective tissue from neoplastic and non-neoplastic colorectal tissues, since it has a central role in tumor development and progression. METHODS Tissue samples from neoplastic and non-neoplastic colorectal tissues were obtained from 64 operated patients who had colorectal carcinoma with no distant metas...
متن کاملMass spectrometry and the emerging field of glycomics.
The biological significance of protein and lipid glycosylation is well established. For example, cells respond to environmental stimuli by altering glycan structures on their surfaces, and cancer cells evade normal growth regulation in part by remodeling their surface glycans. In general, glycan chemical properties differ significantly from those of proteins, lipids, nucleic acids, and small mo...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2015
ISSN: 1422-0067
DOI: 10.3390/ijms161226165